The dysplastic naevus syndrome and endocrine disease.

Dysplastic melanocytic naevus syndrome.

Cutaneous melanoma in children and adolescents and aspects of naevus phenotype in melanoma risk assessment

3 To Jan, Linus and Simon with love 4 5 " The important thing is not to stop questioning. Curiosity has its own reason for existing " A. Einstein 6 7 ABSTRACT Cutaneous malignant melanoma (CMM) is one of the most rapidly increasing cancers in the Swedish population. The aetiology of melanoma is a complex interplay between genetics, host characteristics and environmental factors. The host charac...

Cancer Prone Disease Section

Characterised by families with cutaneous malignant melanoma (CMM) and nervous system tumours. Initially described in a family with malignant melanoma and/or cerebral astrocytoma in eight members over three generations. Astroctytomas and cutaneous malignant melanoma have been identified in a number of well defined syndromes such as neurofibromatosis, Turcot’s, Lynch type II cancer, LiFraumeni an...

Rare association of schizophrenia and unilateral Graves’ disease with contralateral thyroid hemiagenesis in two cases of McCune-Albright syndrome

The classical triad of McCune-Albright syndrome (MAS) consists of polyostotic fibrous dysplasia (FD), skin hyperpigmentation (café-au-lait spots), and endocrine dysfunction, frequently seen in females as precocious puberty. Etiology is genetically based and is explained by mosaicism of activating somatic mutations of the alpha-subunit of Gs protein. Clinical presentation is varied and is depend...

Melanoma-Astrocytoma syndrome

Characterised by families with cutaneous malignant melanoma (CMM) and nervous system tumours. Initially described in a family with malignant melanoma and/or cerebral astrocytoma in eight members over three generations. Astroctytomas and cutaneous malignant melanoma have been identified in a number of well defined syndromes such as neurofibromatosis, Turcot’s, Lynch type II cancer, LiFraumeni an...